The Pan American Health Organization (PAHO) has escalated its emergency response efforts as Storm Melissa poses a significant threat to health systems across the Caribbean and Central America. Operating from its Washington-based command center, PAHO is coordinating with national health ministries, United Nations agencies, and regional disaster response units to ensure the continuity of essential health services. Emergency medical supplies have been pre-positioned in Haiti, while Panama has stockpiled additional resources. Jamaica has activated its national emergency operations center, and Cuba and the Dominican Republic are preparing for the storm’s impact. Key concerns include potential power and water outages in hospitals, the risk of disease outbreaks in overcrowded shelters, and the escalating mental health needs of displaced populations. PAHO emphasizes that restoring access to safe water and sanitation will be critical in preventing health crises and maintaining care delivery. The organization remains vigilant, providing ongoing support and monitoring as Melissa continues its path through the region.