The penultimate week of the 2025/26 NFL regular season arrives with immense playoff implications, set against a backdrop of recent dramatic finishes. Week 16 delivered high-stakes theatrics, headlined by two overtime walk-off victories: the Seattle Seahawks’ 38-37 thriller over the Los Angeles Rams and the Chicago Bears’ 22-16 comeback against the Green Bay Packers.
The drama extended into Sunday, where the Detroit Lions suffered a heartbreaking 24-29 loss to the Pittsburgh Steelers after two offensive pass interference calls nullified potential game-winning touchdowns. This defeat leaves last season’s NFC leaders at 8-7, clinging to faint postseason hopes. Significant shifts occurred in the conference hierarchies as the Jacksonville Jaguars dominated the AFC-leading Denver Broncos 34-20, while the Carolina Panthers seized control of the NFC South with a 23-20 upset over Tampa Bay. The Sunday action culminated with the New England Patriots joining Denver atop the AFC following a 28-24 victory against Baltimore.
The Philadelphia Eagles solidified their dominance by clinching the NFC East title with a 29-18 win over Washington, eliminating Dallas from playoff contention. While Philadelphia remains the only division champion confirmed, nine additional teams secured postseason berths in Week 16, leaving just four spots remaining across both conferences.
AFC playoff qualifiers include Denver, New England, Jacksonville, Los Angeles Chargers, and Buffalo, with Pittsburgh, Houston, Indianapolis, and Baltimore competing for the final two positions. The NFC confirmed Seattle, Chicago, Philadelphia, San Francisco, and Los Angeles Rams, while Carolina, Green Bay, and Detroit vie for remaining slots.
Week 17 features critical matchups with substantial seeding consequences. The Buffalo Bills (11-4) host the Philadelphia Eagles (10-5) at Highmark Stadium, where arctic conditions may influence gameplay. Buffalo trails New England by one game in the AFC East while pursuing conference supremacy. Despite Philadelphia’s overtime victory in their November 2023 meeting, Buffalo enters as field goal favorites riding a four-game winning streak and formidable home advantage (16-1 since early 2024). The matchup hinges on Buffalo’s vulnerable run defense (143.6 yards allowed/game) versus Philadelphia’s resurgent ground game (152.8 yards/game).
Simultaneously, the San Francisco 49ers (11-4) host the Chicago Bears (11-4) at Levi’s Stadium, where both offenses rank among the league’s elite. San Francisco seeks to maintain its five-game winning streak and NFC West leadership aspirations, while Chicago aims to clinch its first division crown since 2018. The Bears leverage additional rest days and league-leading takeaways (31) against a 49ers team combating turnover vulnerabilities. With both teams facing formidable Week 18 opponents, this contest carries vital seeding implications.
As the regular season concludes, teams navigate narrow paths to playoff qualification where any misstep proves catastrophic. Betting markets currently favor the Los Angeles Rams (5.40) as Super Bowl LX favorites, followed closely by Seattle (6.60) and Buffalo (9.60), though odds remain fluid heading into critical weekend matchups.