In a significant escalation of efforts to combat drug trafficking, US military forces conducted strikes on four suspected drug vessels in the eastern Pacific on October 29, 2025, resulting in the deaths of 14 individuals. The operation, authorized by President Donald Trump, was confirmed by US Defence Secretary Pete Hegseth, who stated that the targeted vessels were identified by intelligence agencies as part of known narco-trafficking routes. One survivor was reportedly rescued approximately 400 miles off the coast of Acapulco, with Mexican authorities now leading the coordination efforts. Mexican President Claudia Sheinbaum strongly condemned the strikes, emphasizing the need for adherence to international treaties and calling for urgent discussions with US officials. This incident marks the latest in a series of US military actions targeting suspected drug boats in the Pacific and Caribbean, which have claimed at least 57 lives to date. The strikes have heightened tensions between the US and regional governments, particularly Colombia and Venezuela. The US recently imposed sanctions on Colombian President Gustavo Petro and deployed military assets, including the USS Gerald R. Ford, to the Caribbean. President Trump has accused Venezuelan President Nicolás Maduro of leading a drug-trafficking organization, a claim Maduro vehemently denies. The situation underscores the growing complexities of international drug enforcement efforts and their geopolitical ramifications.